Is dihydrocodeine an opioid or opiate
DihydrocodeineDrug groupsOpioidsDihydrocodeine is an analgesic and antitussive agent from the group of opioids for the treatment of pain and dry coughs. The effects are based on binding to opioid receptors. Dihydrocodeine must not be administered together with MAO inhibitors. The most common possible adverse effects include indigestion, headache, tiredness, drowsiness, rash, and itching. Like other opioids, dihydrocodeine can be abused as an intoxicant and become addictive.
Synonymous: Dihydrocodeinum, Dihydrocodeini hydrochloridum, Dihydrocodeini tartrasPhEur, Dihydrocodeini thiocyanas, Dihydrocodeini hydrogenotartrasProducts
Dihydrocodeine is available in the form of prolonged-release tablets, drops and as a syrup (Codicontin®, Paracodin®, Escotussin®, Makatussin® Syrup). It has been approved in Switzerland since 1957.Structure and properties
Dihydrocodeine (C.18H23NO3, Mr = 301.4 g / mol) is a hydrogenated derivative of codeine. It is found in drugs as dihydrocodeine thiocyanate, dihydrocodeine hydrochloride, or dihydrocodeine tartrate. Dihydrocodein tartrate is a white, crystalline powder that is easily soluble in water and has a bitter taste.
Dihydrocodeine (ATC N02AA08) is centrally analgesic and relieves coughs. The effects are based on binding to opioid receptors. Dihydrocodeine has a stronger effect than codeine.
For the treatment of pain or a dry cough.dosage
According to the specialist information.Contraindications
- Respiratory failure
- Liver disease
- Simultaneous treatment with MAO inhibitors is not indicated.
The complete precautionary measures can be found in the medicinal product information sheet.Interactions
Dihydrocodeine is metabolized by CYP2D6, among others. Corresponding interactions are possible. Further drug interactions can occur with alcohol, central depressant drugs, cimetidine, MAO inhibitors, opioid antagonists, morphine, sildenafil, antitussives and expectorants.unwanted effects
The most common possible adverse effects include digestive disorders such as stomach pain, constipation, dry mouth, nausea and vomiting, headache, fatigue, drowsiness, rash and itching. Like other opioids, dihydrocodeine can be abused as an intoxicant and become addictive.see also
- Medicinal product information (CH)
- Edwards J.E., McQuay H.J., Moore R.A. Single dose dihydrocodeine for acute postoperative pain. Cochrane Database Syst Rev, 2000, CD002760 Pubmed
- European Pharmacopoeia PhEur
- Leppert W. Dihydrocodeine as an opioid analgesic for the treatment of moderate to severe chronic pain. Curr Drug Metab, 2010, 11 (6), 494-506 Pubmed
Conflicts of Interest: None / Independent. The author has no relationships with the manufacturers and is not involved in the sale of the products mentioned.additional Information
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This article was last changed on 5/7/2020.
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