What is two grams of Cephalexin

Keflex 1000 mg film-coated tablets

Other medicines and Keflex

Tell your doctor or pharmacist if you are taking / using, have recently taken / used, or may take / use any other medicines.

Keflex should not be combined with certain antibiotics (e.g. tetracyclines, erythromycin, sulfonamides or chloramphenicol) as their effects can cancel each other out.

Concomitant treatment with Keflex and oral anti-coagulants may lead to a prolongation of the prothrombin time.

The risk of kidney damage can be increased by highly effective dehydrating agents (etacrynic acid, furosemide) or other substances that are potentially harmful to the kidneys such as aminoglycosides (e.g. streptomycin, amikacin, gentamicin, kanamycin and neomycin) and polymyxin (e.g. colistin) when administered at the same time as Cefalexin be increased.

Simultaneous administration of Keflex and probenecid increases the plasma concentration of cefalexin by inhibiting excretion via the kidneys.

Keflex can affect various test results. It is therefore important that you tell your doctor about treatment with Keflex.

Concomitant use of Keflex and metformin (an anti-diabetic drug) may increase the plasma concentration of metformin.

What side effects are possible?

Like all medicines, this medicine can have side effects, although not everybody gets them.

The evaluation of side effects is based on the following frequency indications:

Very often: may affect more than 1 in 10 people
Often: may affect up to 1 in 10 people
Occasionally: may affect up to 1 in 100 people
Rare: may affect up to 1 in 1,000 people
Very rare: may affect up to 1 in 10,000 people
Not known: Frequency not based on the available data

Blood and lymphatic system disorders:

Uncommon: platelet deficiency, changes in the white blood count (neutropenia, leukopenia or eosinophilia).

Nervous system disorders:

Uncommon: hyperactivity, headache, nervousness, fatigue, restlessness, hallucination, confusion and dizziness.

Gastrointestinal disorders:

Uncommon: nausea, vomiting, diarrhea (including isolated Cases of pseudomembranous colitis), indigestion, and abdominal pain.

Very rare: itching in the anus area.

Skin and subcutaneous tissue disorders:

Not Known: A red, scaly, widespread rash with bumps under the skin and blisters at the start of treatment with a fever (acute generalized exanthematous pustulosis). Stop using Keflex if you develop these symptoms and contact your doctor or get medical treatment straight away. See also section 2.

Kidney and urinary tract disorders:

Rare: reversible inflammation of the kidney connective tissue (interstitial nephritis).

Musculoskeletal, connective tissue and bone diseases:

Very rare: joint pain, joint inflammation and joint disease.

Immune system disorders:

Possible allergic reactions are:

Uncommon: rash, hives, itching, swelling (joint swelling) and angioneurotic edema. These symptoms usually disappeared after the drug was stopped.

Very rare: Serious, varied, inflammatory, weeping reddening of the skin and blistered detachment of the epidermis (erythema multiforme, Stevens-Johnson syndrome, Lyell syndrome and toxic necrolysis of the skin), severe allergic (anaphylactic) reactions.

Liver and gallbladder diseases:

Very rare: Inflammation of the liver (hepatitis), jaundice due to biliary blockage and a slight increase in certain liver values ​​(ALT and AST).

Reproductive system and breast disorders:

Uncommon: itching in the pubic area, vaginal inflammation, fungus colonization (moniliasis) and discharge.

Reporting of side effects

If you get any side effects, talk to your doctor or pharmacist. This also applies to side effects not listed in this leaflet. You can also report side effects directly via the national reporting system:

Federal Office for Safety in Health Care Traisengasse 5


Fax: + 43 (0) 50 555 36207 Website: http://www.basg.gv.at/

By reporting side effects you can help provide more information on the safety of this medicine.